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Direct Observation of Glucose Fingerprint Using in vivo Raman Spectroscopy

Journal
Science Advances (Sci. Adv.)
Date
2020.01.24
Abstract
Noninvasive blood glucose monitoring has been a long-standing dream in diabetes management. The use of Raman spectroscopy, which has the advantage of molecular specificity, has been investigated in this regard over the past decade. Previous studies reported their capability of glucose sensing based on indirect evidences, mainly showing statistical correlation to the reference glucose concentration. However, such claims suffer from the lack of demonstration of glucose Raman peaks, which has raised questions regarding the effectiveness of Raman spectroscopy for the purpose of sensing blood glucose. Here, we demonstrate the first direct observation of glucose Raman peaks from in vivo skin. Also, the signal intensities varied proportional to the reference glucose concentrations in three live swine glucose-clamping experiments. Tracking spectral intensity based on the linearity enabled accurate prospective prediction in within-subject and inter-subject models. Our direct demonstration of glucose signal may finalize the long debate about whether glucose Raman spectrum is measured in vivo in transcutaneous glucose sensing.
Reference
Science Advances, 6 (4), eaay5206 (2020)
DOI
https://doi.org/10.1126/sciadv.aay5206